The star actually first became involved with the Scleroderma Research Foundation (SRF) prior to his sister's diagnosis with the chronic disease, which can lead to a hardening and tightening of connective tissue and skin. But it was the death of his beloved sister Gay following a battle with the autoimmune disease scleroderma which transformed him into an avid advocate for raising money to find a cure. How a family tragedy turned Bob Saget into an activist: Bob Saget channeled his grief into helping others and now some of his famous friends are doing the same in the wake of his death.
